In Silico Study of Flavonoids Against Helix pomatia agglutinin Targeting Gut Microbiota

Shivangi Sharma

doi:10.70130/

Authors

Shivangi Sharma Amity University Gwalior Author

DOI:

https://doi.org/10.70130/

Abstract

Flavonoids have critical roles in a wide range of pharmacological, beauty products, neutraceutical, as well as medicinal uses. These have been shown for their cancer-fighting qualities, including antioxidants, anti-inflammatory properties, blood lipid-lowering, including cholesterol-lowering effects. The present paper describes a chemical binding investigation involving flavonoids and Helix pomatia agglutinin (PDB ID: 2CGZ). The results from a computational docking molecular investigation of such variants to investigate the binding affinity, residual interaction, and hydrogen bonding of various polyphenols towards Helix pomatia agglutinin are presented. Flavonoids have a binding attraction value ranging from -5.8 to -6.1 Kcal/mol. The present study indicated that flavonoids could be useful in colon cancer by targeting the bacteria in the intestines, resulting in the production of strong anticancer drugs.

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